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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
18.18
Human Site:
S189
Identified Species:
40
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
S189
I
L
Y
C
D
T
N
S
D
S
L
Q
S
L
K
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
S190
I
L
Y
C
D
T
N
S
D
S
L
Q
S
L
K
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
Y174
N
S
D
C
V
G
S
Y
T
L
I
P
Y
V
V
Dog
Lupus familis
XP_533420
1645
181128
R430
S
E
A
L
Q
S
L
R
E
A
C
E
T
V
G
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
S196
I
L
Y
C
D
T
N
S
D
S
L
Q
S
L
K
Rat
Rattus norvegicus
XP_001073260
1338
150427
T175
E
I
I
C
Q
K
N
T
V
C
T
G
N
Y
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
N174
R
I
R
Q
R
V
D
N
I
E
V
L
T
S
D
Chicken
Gallus gallus
XP_419725
1260
143069
T174
R
K
A
R
T
L
Y
T
G
K
E
L
A
A
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
S176
I
L
Y
C
D
H
N
S
D
S
L
Q
S
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
S174
H
M
R
E
K
F
L
S
D
M
R
T
A
R
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
N175
V
H
I
S
N
R
S
N
A
T
E
V
L
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
6.6
0
N.A.
100
13.3
N.A.
0
0
N.A.
86.6
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
26.6
40
N.A.
100
33.3
N.A.
33.3
20
N.A.
93.3
N.A.
26.6
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
0
0
0
0
10
10
0
0
19
10
0
% A
% Cys:
0
0
0
55
0
0
0
0
0
10
10
0
0
0
0
% C
% Asp:
0
0
10
0
37
0
10
0
46
0
0
0
0
0
19
% D
% Glu:
10
10
0
10
0
0
0
0
10
10
19
10
0
0
10
% E
% Phe:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
10
0
0
10
0
0
10
% G
% His:
10
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
37
19
19
0
0
0
0
0
10
0
10
0
0
0
0
% I
% Lys:
0
10
0
0
10
10
0
0
0
10
0
0
0
0
28
% K
% Leu:
0
37
0
10
0
10
19
0
0
10
37
19
10
46
0
% L
% Met:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
10
0
0
0
10
0
46
19
0
0
0
0
10
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% P
% Gln:
0
0
0
10
19
0
0
0
0
0
0
37
0
0
10
% Q
% Arg:
19
0
19
10
10
10
0
10
0
0
10
0
0
10
0
% R
% Ser:
10
10
0
10
0
10
19
46
0
37
0
0
37
10
0
% S
% Thr:
0
0
0
0
10
28
0
19
10
10
10
10
19
0
10
% T
% Val:
10
0
0
0
10
10
0
0
10
0
10
10
0
19
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
37
0
0
0
10
10
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _